How we measure: Every result is generated on a high-resolution mass spectrometry platform within an extensive, trackable quality management system. Multiple layers of QA and QC, including sample-type-specific control samples run through the complete platform with every batch, injection QCs, and regular instrument calibration, ensure that our results are accurate, consistent, and reproducible.
Every study follows the same path, and we perform each step, from the raw sample to the interpreted, decision-ready result.
It starts with the sample. From biofluids to fixed tissue, we handle each matrix routinely. If you want to use your own samples, we offer to consult you on collection, storage and shipping. We can also source samples via our large partner network to complement your available cohorts or to establish new ones.
Proteins are extracted from the sample, digested into peptides, then purified and desalted.
Peptides are separated by HPLC and measured by high-resolution mass spectrometry, yielding rich raw data.
Spectra become identified, quantified proteins — quality-checked, statistically tested, and prioritized into the candidates that matter.
It is our spectral interpretation engine. VeriDyne Profiler extracts all available spectral information, ensuring no valuable signal goes unnoticed. This deeper read of the data means more confident identifications and richer coverage from the same measurement. With this novel, unbiased approach, you can uncover the unexpected. Unlock the dark proteome.
Explore Profiler →
Your interactive results platform. Navigator lets you explore your data without effort, create, test and validate new hypotheses, and export publication-ready figures or complete project reports, all from a secure web app.
Explore Navigator →The reference data layer beneath the measurements, so every result can be read in a richer biological context. The foundation models built on top of it are in active development.
Real-time quality monitoring. It watches every acquisition as it runs, tracking instrument performance and control samples, so drift is caught and corrected before it reaches your data.
The hardware matters, but the method around it matters more. Our edge is high-resolution measurement on the Orbitrap Astral, run inside disciplined, repeatable workflows.
We combine best in market instrumentation throughout our platform. The Orbitrap Astral and Astral Zoom mass spectrometers coupled to the Vanquish Neo Tandem HPLC allow confident identification and precise quantification across a wide dynamic range, even with short gradients at a throughput of more than 200 samples a day.
We match the acquisition strategy to the question: comprehensive coverage, complete fragment spectra for accurate PTM site localization, or high sensitivity and best quantitative precision.
Interested in special scan modes and method development? We are a team of proteomics experts who develop novel scan modes and targeted assays.
The numbers speak for themselves: >1,000 proteins in neat plasma, >5,000 in enriched plasma, 7,000 in urine, >5,000 in CSF, >11,000 in FFPE cancer samples and even higher coverages in cell lines and frozen tissue samples.
Documented quality management system with multiple layers of QA and QC, including more than 20 SOPs for each sample type and analysis, detailed manufacturing instructions for all buffers, qualification system for every buffer that touches your samples, and tracking of input materials. In addition, we have real-time monitoring of all acquired data to detect and correct any performance drifts instantly. This process ensures that our results are accurate, consistent, and reproducible.
Sample quality is the foundation of every result. We helped define how pre-analytical variation is assessed in biofluid proteomics: quality-marker panels that identify, quantify, and where possible correct sample-related biases before they reach your data.
Not new for us: our team defined quality-marker panels for plasma proteomics: Geyer et al., EMBO Molecular Medicine (2019).
Every study that is executed incorrectly consumes valuable sample material, and, more importantly, wastes time and manpower. In our fast-paced scientific environment, these resources cannot be recovered.
