Mode of action
Reveal how a compound or perturbation reshapes the proteome.
Learning everything about the effect of your compound on the body is crucial to pass clinical approval. The proteome is the readout closest to phenotype for seeing the full biological response, on-target and off. Knowing everything possible about your compound is what makes passing clinical trials achievable.
We offer here the analysis of the full proteome and the changes in the signal pathways by profiling phosphoproteome changes.
What happens in the liver when adding a compound? Send us mouse plasma in pre-clinical stages to get 1,000–5,000 proteins depending on the applied workflow, and up to 10,000 proteins when profiling liver samples. We are frequently working with FFPE cuts and fresh frozen samples.
Do you treat a neurodegenerative disease? What perturbation of the proteome in the CSF will happen? Send us CSF of your mouse model. Are you already in clinical trials? Send us the CSF samples of your study participants to get an extensive readout of up to 6,000 proteins.
In the earliest phases of learning about your compound, we can screen extensive amounts of cell lines or primary culture samples. We measure proteome-wide changes across dose and time and map the pathways that actually move, then connect them to plausible mechanisms you can test. So a mode-of-action story rests on evidence, not inference.
Typical study designs
- Dose- and time-resolved treatment responses on mouse plasma
- Perturbation vs. control pathway mapping
- Resistance-mechanism studies
- On- and off-target response profiling
- Phosphoproteomic readout of pathway activity
Let's plan your study
Every study that is executed incorrectly consumes valuable sample material, and, more importantly, wastes time and manpower. In our fast-paced scientific environment, these resources cannot be recovered.