Metabolic diseases

Metabolic disorders such as type 2 diabetes, obesity, and metabolic dysfunction-associated steatotic liver disease (MASLD) arise from disrupted signaling, enzymatic flux, and inter-organ crosstalk that are often poorly captured at the transcript level. Because much of metabolic regulation is driven by phosphorylation, acetylation, and other modifications that switch metabolic pathways on and off, proteomics provides a direct functional readout of the pathways that govern nutrient handling, insulin signaling, and energy homeostasis. Deep profiling of metabolic tissues such as liver, adipose, skeletal muscle, and pancreatic islets resolves organ-specific molecular signatures, while plasma proteomics captures circulating readouts of systemic metabolic state for scalable, minimally invasive monitoring. Using state-of-the-art mass spectrometry together with our proprietary analysis algorithms, ions.bio enables you to map and quantify regulatory PTMs, enzyme isoforms, and patient-specific variants, defining how metabolic signaling is wired in health and disease. Our innovative workflows support mechanistic studies, biomarker discovery, and target identification across the spectrum of metabolic disease.