Immunology

Immune function is governed by regulatory events that are only partially visible in the transcriptome. Innate pathways such as inflammasome assembly, and the phosphorylation cascades downstream of many immune receptors, operate through protein complex formation, post-translational modification, and localization changes rather than transcription and can therefore only be inferred indirectly from RNA. Deep proteome profiling provides a direct functional readout of these events, resolving how signaling is wired across immune cell types and states. Using state-of-the-art mass spectrometers together with our proprietary analysis algorithms, ions.bio maps and quantifies otherwise uncharted terrain: uncharacterized PTMs, miniproteins, isoforms, and patient-specific sequence variants to build a high-resolution picture of immune signaling. In addition, our immunopeptidomics platform provides identification and quantification of HLA-presented peptides to support antigen discovery, biomarker research, and immunotherapy development. Because mass spectrometry works directly on primary material, it is especially suited to immunology, where many key cell populations cannot be faithfully recapitulated by long-term cell-line culture. Together, these capabilities support mechanistic immunology, pathway dissection, and biomarker discovery across the innate and adaptive compartments.